DOT Physical Multiple Sclerosis | Charlotte NC CDL Certification

Medically reviewed by Dr. Alan M. Tebby, D.C., FMCSA Certified Medical Examiner | Last updated: January 22, 2026

TL;DR: DOT Physical Multiple Sclerosis

DOT physical multiple sclerosis certification is possible for many drivers with MS, particularly those with stable, mild disease. The key factors are functional ability (motor control, vision, cognition), disease stability, and neurologist clearance. Drivers with relapsing-remitting MS in remission or mild stable disease often qualify. Severe disability, significant cognitive impairment, or active relapse are disqualifying until stable. Most MS drivers receive 12-month certificates. At Charlotte DOT Exam Center, we work with your neurologist to evaluate your driving fitness. Call 704-544-3494. $70 flat rate.

Multiple Sclerosis and Commercial Driving

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, causing varying degrees of neurological impairment. For commercial drivers with MS, the unpredictable nature of the disease and potential for progressive disability create unique challenges for DOT certification.

However, MS is not automatically disqualifying for commercial driving. Many people with MS have mild disease, long periods of remission, or slow progression that allows them to continue driving safely. The Federal Motor Carrier Safety Administration evaluates MS drivers based on their current functional ability rather than diagnosis alone.

Under 49 CFR 391.41, drivers must demonstrate that they do not have a condition likely to cause sudden incapacitation and that any physical limitations do not prevent safe vehicle operation. Medical examiners evaluate MS patients individually based on current symptoms, disease activity, and functional capacity.

MS Types and Certification Implications

Relapsing-Remitting MS (RRMS)

The most common form, characterized by distinct relapses followed by recovery:

  • During remission: Often certifiable if functional ability is adequate
  • During relapse: Disqualified until symptoms resolve
  • Frequency of relapses: Frequent relapses may affect certification length
  • Recovery pattern: Complete recovery from relapses is favorable

Secondary Progressive MS (SPMS)

RRMS that has transitioned to progressive worsening:

  • Gradual decline: Requires careful monitoring
  • Certification depends on: Current functional status
  • May require: More frequent re-evaluation
  • Progressive disability: May eventually preclude certification

Primary Progressive MS (PPMS)

Steady progression from onset without distinct relapses:

  • Rate of progression: Varies widely among individuals
  • Early stages: May be certifiable with mild symptoms
  • Monitoring essential: Regular neurologist follow-up required
  • Advanced disease: Often disqualifying due to accumulated disability

Clinically Isolated Syndrome (CIS)

Single episode suggesting MS but not yet diagnosed:

  • After recovery: May be certified with neurologist clearance
  • Monitoring: Regular evaluation for MS development
  • Documentation: MRI findings and clinical assessment

FMCSA Requirements for MS

There is no specific FMCSA regulation for MS. Medical examiners evaluate drivers based on:

Primary Certification Criteria

  • Motor function: Ability to control vehicle with adequate strength and coordination
  • Vision: Meeting visual acuity and field requirements
  • Cognition: Adequate attention, processing speed, and judgment
  • Fatigue: MS-related fatigue must not impair driving safety
  • Bladder/bowel function: Management that doesn’t interfere with driving
  • Disease stability: No active relapse or rapid progression

Disqualifying Factors

  • Active relapse with significant symptoms
  • Severe weakness or spasticity affecting limb control
  • Visual impairment not meeting DOT standards
  • Significant cognitive impairment
  • Severe fatigue causing safety concerns
  • Optic neuritis with unresolved vision loss
Many commercial drivers with stable MS maintain their DOT certification with proper management.

Functional Evaluation for MS Drivers

Motor Function Assessment

  • Upper extremity: Grip strength, fine motor control for steering
  • Lower extremity: Pedal control, rapid movement between pedals
  • Coordination: Smooth, controlled movements
  • Spasticity: Muscle stiffness that could interfere with control
  • Tremor: Intention tremor affecting precision

Sensory Function

  • Position sense: Knowing where limbs are in space
  • Touch sensation: Feeling the steering wheel, pedals
  • Temperature: Uhthoff’s phenomenon (heat sensitivity)
  • Pain: Chronic pain that could distract from driving

Cognitive Assessment

  • Processing speed: Quick decision-making ability
  • Attention: Sustained focus during driving
  • Memory: Short-term memory for navigation, task completion
  • Executive function: Planning, problem-solving while driving

Fatigue Evaluation

MS-related fatigue is one of the most common and potentially disabling symptoms:

  • Severity and pattern of fatigue
  • Strategies for managing fatigue
  • Impact on driving endurance
  • Medications that may help or worsen fatigue

Vision Requirements and MS

MS commonly affects vision, which is critical for commercial driving:

DOT Vision Standards

  • Visual acuity: 20/40 or better in each eye (with or without correction)
  • Horizontal visual field: At least 70 degrees in each eye
  • Color vision: Ability to distinguish traffic signal colors

MS-Related Vision Problems

  • Optic neuritis: Common in MS; may cause temporary or permanent vision loss
  • Nystagmus: Involuntary eye movements affecting visual stability
  • Diplopia: Double vision from eye muscle weakness
  • Visual field defects: May result from optic nerve damage

If you’ve had optic neuritis, bring documentation of your current visual acuity and field testing. Recovered optic neuritis with normal vision is not disqualifying.

MS Medications and DOT Certification

Most MS disease-modifying therapies and symptom management medications are compatible with commercial driving:

Disease-Modifying Therapies

  • Interferons: Avonex, Betaseron, Rebif — generally acceptable
  • Glatiramer acetate: Copaxone — generally acceptable
  • Oral medications: Tecfidera, Gilenya, Aubagio — generally acceptable
  • Infusions: Tysabri, Ocrevus, Lemtrada — evaluated individually

Symptom Management Medications

  • Fatigue: Modafinil, amantadine — monitor for side effects
  • Spasticity: Baclofen, tizanidine — may cause drowsiness
  • Pain: Gabapentin, pregabalin — sedation concerns
  • Bladder: Anticholinergics — generally acceptable

Discuss your medication regimen with the medical examiner. Medications causing significant sedation or cognitive impairment may require adjustment or additional evaluation.

Required Documentation for MS

Neurologist Records

  • MS type and date of diagnosis
  • Disease activity history (relapses, progression)
  • Current symptom status and EDSS score if available
  • Recent MRI findings
  • Current treatment regimen

Clearance Letter

Your neurologist’s letter should address:

  • Current disease status (remission, stable, active)
  • Functional limitations, if any
  • Cognitive status assessment
  • Visual status if optic neuritis history
  • Statement that patient can safely operate commercial motor vehicle

Functional Testing

May be required depending on symptoms:

  • Ophthalmology evaluation if vision concerns
  • Neuropsychological testing if cognitive concerns
  • Physical therapy functional assessment if motor concerns

FAQs: DOT Physical Multiple Sclerosis

Can I get a CDL if I have multiple sclerosis?

Yes, many people with MS can obtain and maintain CDL certification. Certification depends on your current functional ability, disease stability, and neurologist clearance—not simply the diagnosis.

Will MS medications disqualify me from driving commercially?

Most MS medications are compatible with commercial driving. Medications causing significant sedation or cognitive impairment may require evaluation, but standard disease-modifying therapies are generally acceptable.

How often will I need DOT physicals with MS?

Most MS drivers receive 12-month certificates, requiring annual recertification. This allows regular monitoring of disease status and functional ability.

What if I have a relapse after getting my DOT medical card?

You should not drive commercially during an active relapse with significant symptoms. Once you’ve recovered and your neurologist clears you, you can return to driving. Report significant relapses at your next DOT physical.

Can I drive commercially if I use a cane due to MS?

Using a cane for walking doesn’t necessarily affect driving ability. The key question is whether you can safely operate the vehicle controls. If your leg function is adequate for pedal operation, you may be certifiable.

What about MS fatigue and long-haul driving?

MS fatigue is a valid concern. You’ll need to demonstrate that your fatigue is manageable and doesn’t create safety risks. Some drivers with MS fatigue do better with regional rather than long-haul routes.

Key Takeaways: DOT Physical Multiple Sclerosis

  • Not automatically disqualifying: Many MS patients drive commercially
  • Function over diagnosis: Current ability matters more than MS diagnosis
  • Disease stability required: Active relapses are disqualifying
  • Vision critical: Must meet DOT visual standards
  • Fatigue evaluated: MS fatigue must be manageable
  • Neurologist clearance: Essential for certification
  • 12-month certificates: Annual monitoring typical for MS drivers
  • Medications usually acceptable: Most MS medications don’t disqualify

Charlotte DOT Exam Center Location

Address

Charlotte DOT Exam Center
8415 Pineville-Matthews Road, Suite 102
Charlotte, NC 28226

Phone: 704-544-3494

Hours

Monday-Friday: 8:30am – 5:00pm
Saturday: 8:30am – 12:00pm

Walk-Ins Welcome

Have MS? Let’s Discuss Your Options

Charlotte DOT Exam Center evaluates MS drivers for commercial certification based on individual functional status.

Call 704-544-3494

$70 Flat Rate • Walk-Ins Welcome • Same-Day Certification