Medically reviewed by Dr. Alan M. Tebby, D.C., FMCSA Certified Medical Examiner | Last updated: January 22, 2026
TL;DR: DOT Physical Seizures Epilepsy
DOT physical seizures epilepsy requirements are among the strictest FMCSA medical standards. Under standard regulations, drivers must be seizure-free for 8 years and completely off all anti-seizure medications. However, the FMCSA Seizure Exemption Program allows qualified drivers with shorter seizure-free periods (minimum 3 years) to obtain certification with ongoing monitoring. Single provoked seizures may have different requirements than epilepsy. At Charlotte DOT Exam Center, we help drivers understand their options and navigate the exemption application process. Call 704-544-3494. $70 flat rate.
Understanding Seizure Disorders and Commercial Driving Certification
Seizure disorders and epilepsy represent one of the most challenging medical conditions for commercial driver certification due to the fundamental safety concerns they present. The sudden, unpredictable nature of seizures poses obvious and serious safety risks when operating a commercial motor vehicle, which is why FMCSA regulations establish strict requirements for drivers with seizure history.
The Federal Motor Carrier Safety Administration addresses seizures under 49 CFR 391.41(b)(8), which states that a driver is physically disqualified if they have “a clinical diagnosis of epilepsy or any other condition which is likely to cause loss of consciousness.” This standard has been interpreted through FMCSA Medical Advisory Criteria, Medical Expert Panel recommendations, and the Seizure Disorder Exemption Program.
However, advances in seizure management and the FMCSA’s recognition that many epilepsy patients achieve excellent long-term seizure control have created pathways for qualified drivers to obtain certification. Understanding the difference between standard certification requirements and exemption program criteria is essential for drivers with seizure history who want to pursue or maintain commercial driving careers.
FMCSA Standard Requirements for Seizures and Epilepsy
Under standard FMCSA regulations without pursuing an exemption, the requirements for drivers with any seizure history are quite stringent:
8-Year Seizure-Free Requirement
To qualify for standard interstate certification (not through the exemption program), a driver with seizure history must meet all of the following criteria:
- Seizure-free for at least 8 years — No seizures of any type during this entire period, including breakthrough seizures, auras, or partial seizures
- Off all anti-seizure medications for 8 years — Must have completely discontinued all anticonvulsant medication and remained seizure-free without medication
- Cleared by a neurologist — Written documentation confirming seizure-free status, low recurrence risk assessment, and clearance for commercial driving
- No underlying condition likely to cause seizures — Any structural brain abnormality or condition predisposing to seizures must be evaluated
This conservative standard reflects the safety-critical nature of commercial driving and the potential for catastrophic consequences if a seizure occurs while operating a large commercial vehicle. However, the FMCSA recognizes that this standard may be overly restrictive for many drivers who have achieved excellent seizure control through medication.
Single Seizure Evaluation
A single, isolated seizure is evaluated differently than recurrent seizures or diagnosed epilepsy. Medical examiners consider several important factors:
- Whether a clear provoking factor was identified and eliminated
- Results of complete neurological workup (EEG, MRI, laboratory studies)
- Assessed risk of recurrence based on clinical evaluation and testing
- Time elapsed since the seizure occurred
- Whether any treatment was required
FMCSA Seizure Exemption Program
The FMCSA Seizure Disorder Exemption Program provides an alternative certification pathway for drivers who cannot meet the standard 8-year off-medication requirement but have demonstrated excellent, documented seizure control.
Exemption Program Eligibility Requirements
- Seizure-free period: Minimum seizure-free period (requirements have evolved; verify current FMCSA standards) while on a stable medication regimen
- Comprehensive neurologist evaluation: Detailed assessment supporting low seizure recurrence risk
- Stable medication regimen: No medication changes in the specified period prior to application
- No disqualifying seizure types: Certain seizure types or patterns may preclude exemption eligibility
- Clean driving record: No seizure-related motor vehicle accidents or incidents
- Commercial driving experience: Generally requires prior commercial driving experience
Exemption Application Process
- Gather complete documentation: All medical records, neurologist reports, seizure diary, medication records
- Obtain current neurologist evaluation: Recent comprehensive examination and detailed clearance letter
- Submit FMCSA application: Through the official exemption program portal with all required documentation
- Wait for determination: Processing typically takes several months for thorough review
- If approved: Receive exemption letter valid for 2 years with specific conditions
- Ongoing monitoring: Required annual neurologist follow-up and status reporting to FMCSA
Exemption Conditions and Ongoing Monitoring Requirements
Drivers granted seizure exemptions must comply with strict ongoing requirements to maintain their exemption status:
- Annual neurologist evaluation and clearance letter submission
- Immediate reporting of any seizure activity to FMCSA
- Strict compliance with prescribed medication regimen
- Submission of annual status reports to FMCSA on schedule
- Understanding that exemption may be immediately revoked if any seizure occurs
- Carrying exemption documentation while driving commercially

Types of Seizures and Certification Impact
Different seizure types have different implications for commercial driving certification, though all types are taken seriously:
Generalized Tonic-Clonic Seizures (Grand Mal)
These seizures involve complete loss of consciousness and convulsions affecting the entire body. They are the most concerning for commercial driving because they cause complete incapacitation without warning. Drivers with history of tonic-clonic seizures face the strictest requirements and longest seizure-free period expectations.
Absence Seizures (Petit Mal)
Brief episodes of staring and unresponsiveness, typically lasting only seconds, may seem less severe but still represent loss of awareness that could be extremely dangerous while operating a commercial vehicle. These require the same seizure-free periods as other seizure types for certification purposes.
Focal (Partial) Seizures
Seizures affecting only part of the brain may or may not involve alteration of consciousness. Focal seizures with impaired awareness are treated similarly to generalized seizures for certification purposes. Focal seizures without impaired awareness may be evaluated somewhat more favorably by neurologists, but still require comprehensive documentation and adequate seizure-free periods.
Nocturnal Seizures
Seizures occurring exclusively during sleep present a unique evaluation challenge. While the seizure itself may not occur during driving, the underlying seizure disorder still poses potential risk and indicates brain hyperexcitability. These cases require careful neurologist evaluation of seizure risk during waking hours.
Provoked vs Unprovoked Seizures
The distinction between provoked and unprovoked seizures is critical for DOT certification evaluation:
Provoked (Acute Symptomatic) Seizures
Seizures caused by an identifiable, correctable provoking factor may be viewed more favorably for certification purposes:
- Medication-induced: Seizure caused by specific medication side effect, interaction, or withdrawal
- Metabolic: Severe hypoglycemia, electrolyte imbalances, kidney or liver failure
- Toxic: Alcohol withdrawal seizures, drug intoxication or withdrawal
- Acute brain injury: Seizure within 7 days of head trauma, stroke, infection, or surgery
- Post-surgical: Seizure immediately following brain surgery (early post-operative)
If the provoking factor has been definitively eliminated and comprehensive workup shows no underlying seizure disorder or brain abnormality, drivers may qualify for certification with shorter waiting periods and appropriate neurologist clearance documentation.
Unprovoked Seizures and Epilepsy
Seizures without an identifiable provoking factor, or two or more seizures occurring more than 24 hours apart, typically indicate epilepsy requiring the full seizure-free period or exemption program qualification. The risk of recurrence is significantly higher with unprovoked seizures.
Required Documentation for Seizure History
Thorough, complete documentation is absolutely essential for any driver with seizure history:
Medical Records Required
- Complete seizure history: Dates, detailed descriptions, and circumstances of all seizures ever experienced
- All EEG results: Every electroencephalogram study performed, with interpretations
- Brain imaging: MRI and/or CT scan reports documenting brain structure
- Complete neurologist notes: All evaluation, follow-up, and treatment documentation
- Medication records: All anti-seizure medications prescribed past and present, with dates started and stopped
- Hospital records: All emergency room visits and hospitalizations related to seizures
Neurologist Clearance Letter Requirements
The neurologist clearance letter must comprehensively include:
- Complete diagnosis with seizure type classification
- Exact date of last seizure of any type
- Current medication, dosage, and schedule
- Assessment of medication compliance
- EEG interpretation and significance
- Detailed risk assessment for seizure recurrence
- Clear, unequivocal statement regarding fitness for commercial motor vehicle operation
Seizure Diary Documentation
Maintaining a detailed seizure diary helps demonstrate and document seizure-free status:
- Documentation showing complete absence of seizure activity
- Any questionable events and their professional evaluation
- Medication compliance records with timestamps
- Sleep patterns (particularly relevant for nocturnal seizure history)
Anti-Seizure Medications and DOT Certification
Many anti-seizure medications are compatible with commercial driving when properly managed and side effects are minimal:
Commonly Used Anticonvulsant Medications
- Levetiracetam (Keppra): Generally well-tolerated with minimal sedation in most patients
- Lamotrigine (Lamictal): Low sedation profile, commonly used
- Carbamazepine (Tegretol): May cause initial drowsiness that typically improves
- Phenytoin (Dilantin): Long-established medication with known side effect profile
- Valproic acid (Depakote): May cause sedation in some patients
- Topiramate (Topamax): May affect cognition and word-finding in some patients
- Oxcarbazepine (Trileptal): Similar profile to carbamazepine
- Lacosamide (Vimpat): Newer medication with generally favorable tolerability
Medication Considerations for Certification
The medical examiner and neurologist evaluate:
- Whether the medication causes significant sedation or cognitive impairment
- Medication stability (same dose for extended period without changes)
- Documented compliance with the medication regimen
- Therapeutic drug levels if monitored
- Any breakthrough seizures while on current regimen
Taking anti-seizure medication does not automatically disqualify a driver, but the exemption program is required if still taking medication (since standard certification requires 8 years completely off all medication).
FAQs: DOT Physical Seizures Epilepsy
Can I get a CDL if I have epilepsy?
Yes, it is possible through the FMCSA Seizure Exemption Program for interstate driving. You must demonstrate excellent, documented seizure control, meet the program’s seizure-free requirements, and obtain comprehensive neurologist clearance. The standard 8-year seizure-free and off-medication requirement is difficult to meet, but the exemption program provides an alternative pathway for qualified drivers.
How long must I be seizure-free for a DOT physical?
Under standard regulations without exemption, 8 years completely seizure-free and off all anti-seizure medication. Through the exemption program, requirements may be shorter but typically still require multiple years of documented seizure freedom with well-documented excellent control on stable medication.
Will taking seizure medication disqualify me from commercial driving?
Under standard regulations, yes—you must be off all medication for 8 years. However, the FMCSA Seizure Exemption Program specifically allows drivers on stable anti-seizure medication regimens to qualify if they meet other program criteria and maintain ongoing compliance.
I had one seizure years ago. Can I still get certified?
Possibly. A single provoked seizure with a clearly identified cause that has been definitively corrected may be evaluated more favorably than diagnosed epilepsy. A single unprovoked seizure still requires careful evaluation, but the 8-year standard typically applies to epilepsy (defined as recurrent unprovoked seizures) rather than a single isolated event with identified cause.
What if I have a seizure after getting my CDL?
You must immediately stop driving commercially and report the seizure. Your medical certificate becomes invalid, and you would need to restart the entire qualification process, including meeting seizure-free requirements again from the date of the most recent seizure.
Do childhood seizures affect my DOT certification as an adult?
Childhood seizures that resolved completely and have not recurred may not disqualify you, especially if you’ve been seizure-free for 8+ years since and are off all medication. You’ll need comprehensive neurologist documentation confirming no current seizure disorder and low recurrence risk.
Key Takeaways: DOT Physical Seizures Epilepsy
- Standard requirement: 8 years completely seizure-free AND off all medication
- Exemption program available: Allows certification with medication and shorter seizure-free periods for qualified drivers
- Neurologist clearance required: Comprehensive documentation absolutely essential
- Seizure type matters: All types are disqualifying but provoked single seizures may have different criteria
- Ongoing monitoring required: Exemption requires annual neurologist evaluation and FMCSA reporting
- Any seizure ends certification: A single seizure after certification requires complete restart of the process
- Professional guidance recommended: Complex cases benefit from experienced medical examiners
Charlotte DOT Exam Center Location
Address
Charlotte DOT Exam Center
8415 Pineville-Matthews Road, Suite 102
Charlotte, NC 28226
Phone: 704-544-3494
Hours
Monday-Friday: 8:30am – 5:00pm
Saturday: 8:30am – 12:00pm
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Questions About Seizure Certification?
Charlotte DOT Exam Center can help you understand your options for certification with seizure history.
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I am the administrator for the Charlotte DOT Exam facility, located in Charlotte NC. I oversee the facility services providing DOT exams in accordance with the standards of the FMCSA. We also provide DOT drug testing with MRO support when required. Drug testing can also be done for non-DOT exams such as pre-employment. In order to minimize wait times, I always encourage our clients to contact us first and make an appointment.
I would also suggest that each individual wanting to test for the CDL health card read the article “Preparing For Your DOT Exam” as it lists several things to bring to the test, such as CPAP usage reports and medicine lists.










